CXCL13 can be produced by dendritic cells (DCs). (16189275)
For example, CSD granulomas in vivo contain CXCL13-producing DCs. (16189275)
Chemokines
Chemokines constitute a family of small (approximately 8 to 14 kD) chemotactic cytokines that direct the migration of leukocytes during inflammation and may be involved in the constitutive homing of lymphocytes into follicles and T-cell zones. They act through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
Chemokines are divided into 2 major subfamilies, CXCs and CCs, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXCs chemokines and are adjacent in CCs chemokines.
CXCs chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR types are chemotactic for lymphocytes.
References
Vermi W, Facchetti F, Riboldi E, Heine H, Scutera S, Stornello S, Ravarino D, Cappello P, Giovarelli M, Badolato R, Zucca M, Gentili F, Chilosi M, Doglioni C, Ponzi AN, Sozzani S, Musso T. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma. Blood. 2006 Jan 15;107(2):454-62. PMID: 16189275
Ansel, K. M.; Harris, R. B. S.; Cyster, J. G. : CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16: 67-76, 2002. PubMed ID : 11825566
Husson, H.; Freedman, A. S.; Cardoso, A. A.; Schultze, J.; Munoz, O.; Strola, G.; Kutok, J.; Carideo, E. G.; De Beaumont, R.; Caligaris-Cappio, F.; Ghia, P. : CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Brit. J. Haemat. 119: 492-495, 2002. PubMed ID : 12406091
Legler, D. F.; Loetscher, M.; Roos, R. S.; Clark-Lewis, I.; Baggiolini, M.; Moser, B. : B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187: 655-660, 1998. PubMed ID : 9463416