CDK4
12q13
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CDK4 forms a complex with cyclin D. The complex phosphorylates RB, allowing the cell to progress through the G1 restriction point.
Pathology
amplification and/or overexpression in tumors
-
liposarcomas (16160477)
- atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) (16160477)
- dedifferentiated liposarcoma (DDLPS) (16160477)
pulmonary carcinomas (lung cancer)
melanomas (16419059)
See also
P16(INK4A)-CDK4/6-RB pathway
12q13 amplification
References
Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P, Pedeutour F. Detection of MDM2-CDK4 Amplification by Fluorescence In Situ Hybridization in 200 Paraffin-embedded Tumor Samples: Utility in Diagnosing Adipocytic Lesions and Comparison With Immunohistochemistry and Real-time PCR. Am J Surg Pathol. 2007 Oct;31(10):1476-1489. PMID: 17895748
Shimada S, Ishizawa T, Ishizawa K, Matsumura T, Hasegawa T, Hirose T. The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers. Hum Pathol. 2006 Sep;37(9):1123-9. PMID: 16938516
Muthusamy V, Hobbs C, Nogueira C, Cordon-Cardo C, McKee PH, Chin L, Bosenberg MW. Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosomes Cancer. 2006 May;45(5):447-54. PMID: 16419059