Human pathology

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CD117

c-kit

The proto-oncogene c-kit is a receptor tyrosine kinase recognized to initiate essential signal transduction pathways that transmit biological signals for cellular proliferation, differentiation, and metastasis. Aberrant expression or mutation of c-kit has been shown to be involved in the pathogenesis of many cancers.

Pathology

- germline mutations

- somatic mutations

- overexpression in tumors

Diagnostic use

- positive diagnosis of renal oncocytoma (71%) (15105658)
- positive diagnosis of renal chromophobe renal cell carcinoma (88%) (15105658)

References

- Druker BJ. STI571 (Gleevec) as a paradigm for cancer therapy. Trends Mol Med. 2002;8(4 Suppl):S14-8. PMID: 11927282