CAMTA1 (calmodulin-binding transcription activator 1) gene spans a minimal region of 1p36 loss in gliomas with oligodendrial differentiation but is not subject to somatic mutations. CAMTA1 expression is cell cycle dependent, being higher in the S and M phases. CAMTA1 is a putative 1p36 cancer gene.
Pathology
Hemizygous deletion of chromosome 1p is common in many cancers, including many oligodendrogliomas (where it is a favorable prognostic marker) and neuroblastomas (NB) (where it is a negative prognostic marker), and some Ewing sarcomas (EWS).
See also
References
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Katoh M, Katoh M. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Int J Oncol. 2003 Oct;23(4):1219-24. PMID: 12964007