Pathology
Inactivation in human cells of several components of the Pes1-Bop1 complex (BOP1, GRWD1, PES1, ORC6L, and RPL3), involved in ribosome biogenesis, alters chromosome segregation.
Dosage increase of the BOP1 gene is a frequent event during colorectal tumorigenesis (detected in 39% of the tumors)
Transient overexpression of BOP1 in human cells increased the percentage of multipolar spindles. (16804918)
See also
colorectal tumorigenesis
ribosome biogenesis
References
Killian, A.; Le Meur, N.; Sesboue, R.; Bourguignon, J.; Bougeard, G.; Gautherot, J.; Bastard, C.; Frebourg, T.; Flaman, J.-M. : Inactivation of the RRB1-pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. Oncogene 23: 8597-8602, 2004. PubMed ID : 15467761
Killian, A.; Sarafan-Vasseur, N.; Sesboue, R.; Le Pessot, F.; Blanchard, F.; Lamy, A.; Laurent, M.; Flaman, J.-M.; Frebourg, T. : Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. Genes Chromosomes Cancer 45: 874-881, 2006. PubMed ID : 16804918