BOP1

Pathology

 Inactivation in human cells of several components of the Pes1-Bop1 complex (BOP1, GRWD1, PES1, ORC6L, and RPL3), involved in ribosome biogenesis, alters chromosome segregation.

 Dosage increase of the BOP1 gene is a frequent event during colorectal tumorigenesis (detected in 39% of the tumors)

• it is associated with an increase of BOP1 mRNA. (16804918)

 Transient overexpression of BOP1 in human cells increased the percentage of multipolar spindles. (16804918)

See also

 colorectal tumorigenesis
 ribosome biogenesis

References

 Killian, A.; Le Meur, N.; Sesboue, R.; Bourguignon, J.; Bougeard, G.; Gautherot, J.; Bastard, C.; Frebourg, T.; Flaman, J.-M. :
Inactivation of the RRB1-pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. Oncogene 23: 8597-8602, 2004. PubMed ID : 15467761

 Killian, A.; Sarafan-Vasseur, N.; Sesboue, R.; Le Pessot, F.; Blanchard, F.; Lamy, A.; Laurent, M.; Flaman, J.-M.; Frebourg, T. : Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. Genes Chromosomes Cancer 45: 874-881, 2006. PubMed ID : 16804918