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BOOP

Bronchiolitis obliterans organizing pneumonia (BOOP) is a ubiquitous entity, known to occur either idiopathically or in association with various pulmonary disorders.

Synopsis

- myxomatous connective tissue plugs present in the lumen of bronchioles with extension into the alveoli
- Masson bodies (serpiginous plugs of fibroblastic tissue filling the alveolar spaces)
- focal fibrosis of some alveolar septa
- reactive pneumocytic hyperplasia

Etiology

- organizing pulmonary infections

- organ allograft

- organizing diffuse alveolar damage (scarring DAD)

- distal to bronchial obstruction

- aspiration penumonia

- drug reactions

- toxic reactions

- dysimmunity

- extrinsic allergic alveolitis (hypersensitivity pneumonia)
- chronic eosinophilic pneumonia
- chronic bronchiolitis
- diffuse panbronchiolitis

- nonspecific reactions

- unknown cause (idiopathic BOOP)

Differential diagnosis

- pulmonary organizing diseases
- constrictive bronchiolitis

See also:

- bronchiolitis obliterans syndrome (BOS)
- chronic airway rejection
- obliterative bronchiolitis

- pulmonary lesions

- pulmonary lesional syndromes

  • bronchiolar lesional syndromes

References

References

- Proliferative activity in fibrosing lung diseases: a comparative study of Ki-67 immunoreactivity in diffuse alveolar damage, bronchiolitis obliterans-organizing pneumonia, and usual interstitial pneumonia. El-Zammar O, Rosenbaum P, Katzenstein AL. Hum Pathol. 2009 Apr 13. PMID: 19368952

- Siddiqui MT, Garrity ER, Husain AN. Bronchiolitis obliterans organizing pneumonia-like reactions: a nonspecific response or an atypical form of rejection or infection in lung allograft recipients? Hum Pathol. 1996 Jul;27(7):714-9. PMID: 8698317

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