BCR/ABL
Image Gallery
Tyrosine kinase overexpression.
Pathology
BCR-ABL fusion gene in B-lineage acute lymphoblastic leukemia by t(9;22)(q34;q11)
Reviews
Schiffer CA. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N Engl J Med. 2007 Jul 19;357(3):258-65. PMID: 17634461
Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A, Griffin JD. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer. 2007 May;7(5):345-56. PMID: 17457302
O?hare T, Corbin AS, Druker BJ. Targeted CML therapy: controlling drug resistance, seeking cure. Curr Opin Genet Dev. 2006 Feb;16(1):92-9. PMID: 16343892
Giles FJ, Cortes JE, Kantarjian HM. Targeting the Kinase Activity of the BCR-ABL Fusion Protein in Patients with Chronic Myeloid Leukemia. Curr Mol Med. 2005 Nov;5(7):615-23. PMID: 16305488
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005 Mar;5(3):172-83. PMID: 15719031
Slupianek, A.; Schmutte, C.; Tombline, G.; Nieborowska-Skorska, M.; Hoser, G.; Nowicki, M. O.; Pierce, A. J.; Fishel, R.; Skorski, T. : BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance. Molec. Cell 8: 795-806, 2001. PubMed ID : 11684015
References
Patel H, Marley SB, Gordon MY. Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2. Genes Chromosomes Cancer. 2006 Dec;45(12):1121-9. PMID: 16955467