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ARHGEF5

The ARHGEF5/TIM oncogene belongs to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Rho-GEFs play an important role in tumorigenesis and metastasis through the activation of their substrates, the Rho GTPases. MIM.600888

Pathology

- five novel ARHGEF5/TIM alternative transcripts specifically expressed in breast tumors. These variant transcripts were characterized by the absence of one or several exons, all coding for the catalytic Dbl-homology (DH) domain and generating modified or truncated predicted variant proteins. (14662653)

- expression of recombinant ARHGEF5/TIM protein in transfected COS-7 and NIH-3T3 cells generated a loss of actin stress fibers and the formation of membrane ruffles and filopodia. (14662653)

- ARHGEF5/TIM activates Rac1, Cdc42 or RhoG rather than RhoA, as previously demonstrated in in vitro guanine nucleotide exchange assays. (14662653)

P.S.

- MIM.600888

Keywords