Members of the AKT protein family (AKTs) are implicated in numerous biologic processes, including adipocyte and muscle differentiation, glycogen synthesis, glucose uptake, apoptosis, and cellular proliferation
The serine/threonine protein kinase AKT1 (also known as PKB, protein kinase B) is thought to be a key mediator of signal transduction processes. The identification of AKT1 substrates and the role AKT1 phosphorylation plays in regulating these molecules have been a major focus of research in recent years. AKT1 plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling.
Members
| AKT1 | AKT2 | AKT3 |
Features
AKT-PIP3 signaling pathway
References
Kumar R, Hung MC. Signaling intricacies take center stage in cancer cells. Cancer Res. 2005 Apr 1;65(7):2511-5. PMID: 15805240
Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci. 2001 Aug;114(Pt 16):2903-10. PMID: 11686294