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AKT2
Friday 2 February 2007
Definition: AKT2 (MIM.164731) is the isoform of AKT 1 and is enriched in insulin-responsive tissues and has been implicated in the metabolic actions of the hormone.
Pathology
An activating mutation of AKT2 and human hypoglycemia. (21979934)
AKT2 mutations and/or amplification in tumors
- ovarian carcinomas (16839745, 16721043)
- pancreatic carcinomas (14735903)
- mammary carcinomas (12032855)
- embryonal rhabdomyosarcoma (16790082)
See also
AKTs
References
An activating mutation of AKT2 and human hypoglycemia. Hussain K, Challis B, Rocha N, Payne F, Minic M, Thompson A, Daly A, Scott C, Harris J, Smillie BJ, Savage DB, Ramaswami U, De Lonlay P, O’Rahilly S, Barroso I, Semple RK. Science. 2011 Oct 28;334(6055):474. PMID: 21979934