thecoma
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ovarian thecoma, theca cell tumors
Synopsis
Age at diagnosis: Usually > 40 years old (65% post-menopausal)
+/- hormonally active (estrogenic or androgenic)
usually benign
Macroscopy: unilateral (in 90% of cases), well defined, firm, solid, covered by intact ovarian serosa; usually yellow
spindle cells
- moderate pale cytoplasm containing lipid droplets
- central nuclei
stroma
- collagen deposition
- focal hyaline plaque formation
- +/- heavily calcified
- +/- prominent stromal hyperplasia (hyperthecosis)
fat stains + (on fresh/frozen tissue)
- Oil red O +
- Sudan black + (fat stains)
silver stains
- reticulin fibers surrounding individual cells
Variants
luteinized thecoma
- thecoma with steroid hormone secreting cells
- edema
- focal mitotic activity
Leydig cell containing thecoma
- cytoplasmic Reinke crystalloids
Cytogenetics
trisomy 12
tetrasomy 12 (11148462)
See also
sex cord-stromal tumors