Etiology
primary spontaneous pneumothorax
- mutations of FLCN gene at 17p11.2 coding for folliculin (MIM.607273)
secondary spontaneous pneumothorax
- Birt-Hogg-Dube syndrome (MIM.135150) (FLCN mutations at 17p11.2)
- heritable disorders of connective tissue
- Marfan syndrome
- Ehlers-Danlos syndromes