Synopis
indolent disease
leukemic involvement by lymphoid cells, including prolymphocytes and/or paraimmunoblasts
splenomegaly
Immunochemistry
Pan-B+;
CD5+
CD23+
CD10-
sIgM+ faint
Putative cell of origin:
CD5+ virgin B-cell with germline IgV genes
Cytogenetics
del(6)(q21-23) (20-30% of the cases)