Sacrococcygeal teratoma (SCT) is the most common tumor of the newborn with an incidence of 1 in 35,000 to 40,000 live births. In the newborn, the sacrococcygeal site is located at the base of the tailbone (coccyx), is the most common location of teratomas in newborns.
Cytogenetics
constitutional partial monosomy 7q (14663834)
constitutional trisomy 2p (14663834)
constitutional t(12;15)(q13;q25) pat (12165446)
Predisposition
- presacral teratoma
- anterior meningocele
- sacral agenesis
- anorectal malformation
References
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Drut R. Histopathology. 2009 May;54(6):763; PMID: 19438750
Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Busch C, Oppitz M, Wehrmann M, Schweizer P, Drews U. Histopathology. 2008 May;52(6):717-30.PMID: 18439155
Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004 Sep-Dec;23(5-6):295-303. PMID: 16137166
Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: 15613854
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol. 1998 Sep;22(9):1115-24. PMID: 9737245