retroperitoneal lipoma
Differential diagnosis
Adipose tissue tumors of the retroperitoneum showing no identifiable cytologic atypia are usually classified as lipomalike well-differentiated liposarcoma.
Whether a subset of these tumors represents true examples of retroperitoneal lipoma remains a controversial subject, because the diagnostic liposarcoma cells may be of difficult identification, even after extensive sampling.
Synopsis
no evidence of cytologic atypia.
Cytogenetic
t(3;12)(q27;q14-15) (18551755)
MDM2 and CDK4 amplification (18551755)
HMGA2 balanced rearrangement (18551755)
Molecular biology
HMGA2-LPP fusion gene (18551755)
References
Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG, Oliveira AM. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008 Jun;32(6):951-4. PMID: 18551755