pulmonary sclerosing hemangioma
Sclerosing hemangioma (SH) is an uncommon pulmonary tumor thought to derive from primitive respiratory epithelium consisting of 2 cell populations (cuboidal surface and polygonal stromal cells) and sharing some clinical characteristics (frequent occurrence in nonsmoking women of Asian ethnicity) with bronchioloalveolar carcinoma with which it has been suggested a possible common origin.
Synopsis
endobronchial polyp with bronchial obstruction (14704717)
four architectural patterns
- papillary pattern
- solid pattern
round cells coexpressing thyroid transcription factor-1 and epithelial membrane antigen without cytokeratin immunoreactivity
Immunochemistry
TTF-1+ (thyroid transcription factor-1)
EMA+
CK-
Associations
familial adenomatous polyposis (15188145)
Molecular biology
EGFR expression
p16 locus LOH (17895751)
RB locus LOH (17895751)
References
Sartori G, Bettelli S, Schirosi L, Bigiani N, Maiorana A, Cavazza A, Rossi G. Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung. Am J Surg Pathol. 2007 Oct;31(10):1512-1520. PMID: 17895751