Human pathology

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pulmonary carcinomas

lung carcinomas, lung cancers

Types

- pulmonary adenocarcinoma
- pulmonary squamous cell carcinoma
- pulmonary pleomorphic carcinoma
- pulmonary mucinous carcinoma

Familial susceptibility loci

- 6q23-25 (15272417)

Oncogenetics

- 51 genomic regions with homozygous deletions (HDs) (17674361)

Fusion genes

- EML4/ALK fusion gene in non-small-cell lung cancer (17625570)

Reviews

- Wistuba II. Genetics of preneoplasia: lessons from lung cancer. Curr Mol Med. 2007 Feb;7(1):3-14. PMID: 17311529

- Meuwissen R, Berns A. Mouse models for human lung cancer. Genes Dev. 2005 Mar 15;19(6):643-64. PMID: 15769940

References

- Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers?a different disease. Nat Rev Cancer. 2007 Oct;7(10):778-90. PMID: 17882278

- Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Jul 11; PMID: 17625570

- Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J. Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer. 2007 Aug 2; PMID: 17674361