Microscopy
malignant glandular structures with central lumina
some of which contain intraluminal mucinous-like material.
extensive areas of necrosis
Types
pulmonary acinar adenocarcinoma
pulmonary papillary adenocarcinoma
pulmonary bronchioloalveolar adenocarcinoma
pulmonary solid adenocarcinoma
pulmonary clear cell adenocarcinoma
pulmonary mucinous adenocarcinoma (colloid )
pulmonary mucinous cystadenocarcinoma
pulmonary signet ring adenocarcinoma
pulmonary mixed adenocarcinoma
pulmonary fetal adenocarcinoma
- low-grade adenocarcinoma of fetal lung type (L-FLAC)
- high-grade adenocarcinoma of fetal lung type (H-FLAC)
Variants
pulmonary adenocarcinomas with enteric differentiation (15832091)
Comparative genomic hybridization (CGH)
CGH revealed regions on 1q, 2p, 3q, 5p, 5q, 7p, 8q, 11q, 12q, 14q, 16p, 17p, 19q, 20q, 21q, and 22q to be commonly overrepresented and regions on 2q, 3p, 4p, 5q, 7q, 8p, 9p, 13q, 14q, and 17p to be underrepresented.
16p13 gain (50%)
- 16p13 amplification was associated with relatively poor differentiation and late stage.
Videos
Pulmonary adenocarcinoma by Washington Deceit
References
Shen H, Zhu Y, Wu YJ, Qiu HR, Shu YQ. Genomic alterations in lung adenocarcinomas detected by multicolor fluorescence in situ hybridization and comparative genomic hybridization. Cancer Genet Cytogenet. 2008 Mar;181(2):100-7. PMID: 18295661
Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, Imoto I, Inazawa J, Hirohashi S. Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res. 2005 Sep 1;11(17):6177-85. PMID: 16144918