pulmonary BMA-SMAV
Definition: Pulmonary localization of bone marrow allograft associated-small muscular arteries vasculopathy (pulmonary BMA-SMAV).
Synopsis
concentric intimal hyperplasia
concentric medial hyperplasia
luminal narrowing
prominent myxoid change
extravasated red blood cells
some foamy histiocytes with no evidence of thrombotic microangiopathy
Complications
digestive ischemia (digestive BMA-SMAV)
- intestinal ischemia (intestinal BMA-SMAV)
- diffuse alveolar damage (DAD)
-
pulmonary hemorrhages
- diffusee alveolar hemorrhages (DAH)
Pathogeny
The cause of this unusual vasculopathy present in patients after BMT is likely to be multifactorial, involving effects of irradiation, chemotherapy, cyclosporine, and GVHD.
Differential diagnosis
bone marrow allograft (BMA)
- graft-versus-host disease (GVHD)
- opportunistic infections
- drug toxicity
- thrombotic microangiopathy (TMA)
- veno-occlusive disease (VOID)
- vasculopathy of small muscular arteries (VSMA)
- digestive VSMA (intestinal VSMA)
- pulmonary VSMA
See also
intestinal vasculitis
References
Selby DM, Rudzki JR, Bayever ES, Chandra RS. Vasculopathy of small muscular arteries in pediatric patients after bone marrow transplantation. Hum Pathol. 1999 Jul;30(7):734-40. PMID: 10414490