Tumoral calcinosis is an uncommon familial disease suggesting an autosomal recessive gene pattern, often with laboratory findings of hyperphosphatemia and normocalcemia.
Tumoral calcinosis is also a rare complication of chronic hemodialysis whose mechanism is incompletely understood. Secondary hyperparathyroidism plays a key role by in the pathogenesis of tumoral calcinosis complicating hemodialysis.
Renal failure
In renal failure patients, tumoral calcinoses are observed as a result of secondary hyperparathyroidism.
The primary conservative therapy conducted with dietetic measures and phosphate-binding medication may not prevent the progression of the massive polytopic foci. A subtotal parathyroidectomy can cause a rapid complete regression of the tumours. Renal failure patients with tumoral calcinosis should undergo subtotal parathyroidectomy after initial conservative therapy. (18693124, 13680142)
Localization
bilateral hip
bilateral hand
Synopsis
calcinosis cutis of the skin
bone changes
References
Complete reversal of tumoral calcinosis after subtotal parathyroidectomy in a hemodialysis patient. Younes M, Belghali S, Zrour-Hassen S, Béjia I, Touzi M, Bergaoui N. Joint Bone Spine. 2008 Oct;75(5):606-9. PMID: 18693124
Tumoral calcinosis of bilateral hip. Chen YL, Chang WC, Chu SJ, Tsai SH. Emerg Med J. 2008 Feb;25(2):97. PMID: 18212146
Tumoral calcinosis in bilateral facet joints of the lumbar spine in scleroderma. Case report. Shibuya S, Kawaguchi Y, Arima N, Yamamoto T, Dobashi H, Tokuda M. J Neurosurg Spine. 2006 Nov;5(5):451-4. PMID: 17120897
Tumoral calcinosis: a case report and review of the literature. Viegas SF, Evans EB, Calhoun J, Goodwiller SE. J Hand Surg Am. 1985 Sep;10(5):744-8. PMID: 4045164