Types
intraneural perineurioma
sclerosing perineurioma
malignant perineurioma
Localixation
cutaneous perineurioma
abdominal visceral perineurioma
soft tissue perineurioma (15958848)
- abdominal soft tissue perineurioma
Cytogenetics (by subtypes)
- 46XX,del(10)(q22q24),der(10),del(22)(q11-12q?)/47, idem,+der(10) (sclerosing perineurioma)
- 46,XY,t(2;10)(p23;q24) (16096405) (sclerosing perineuriomas) (16096405)
47,XX,add(3)(q23),add(6)(q21),-5,-9,-10,-22,+mar1,+mar2,+mars (16096405)
intraneural perineurioma
- 45,XX,add(14)(p13),-22,add(22)(q11.2)
- 46,XX,add(2)(q11.2),add(3)(q12) (16096405)
abdominal soft tissue perineurioma
- 46,XX,t(8;9)(q13;q22) (16096405)
Cytogenetics (by cytogenetic anomalies)
translocations
- t(2;10)(p23;q24)
- t(8;9)(q13;q22)
deletions
- del(10)(q22q24)
- del(22)(q11-12q?)
Gene mutations
somatic mutations or deletions of NF2
References
Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005 Sep;29(9):1164-9. PMID: 16096405
Balarezo FS, Muller RC, Weiss RG, Brown T, Knibbs D, Joshi VV. Soft tissue perineuriomas in children: report of three cases and review of the literature. Pediatr Dev Pathol. 2003 Mar-Apr;6(2):137-41. PMID: 12545405