pericytic tumors
perivascular tumors
Cytogenetics
translocation t(7;12)(p22;q13) (7p22 and 12q13) in pericytomas
- The t(7;12)(p22;q13), fuses the ACTB gene in 7p22, to the GLI1 gene in 12q13 (ACTB/GLI1 fusion gene)
Molecular biology
ACTB/GLI1 fusion gene by translocation t(7;12)(p22;q13)
- fusion of ACTB gene in 7p22 with GLI1 gene in 12q13
References
Dahlin A, Fletcher CDM, Mertens F, Fletcher JA, Perez-Atayde AR, Hicks MJ, Debiec-Rychter M, Sciot R, Wejde J, Wedin R, Mandahl N, Panagopoulos I. Activation of the GLI oncogene through fusion with the beta-actin (ACTB) gene in a group of distinctive pericytic neoplasms: Òpericytoma with t(7;12). Am J Pathol 2004; 164: 1645-1653 PMID: 15111311
Dahlin A, Mertens F, Mandahl N, Panagopoulos I. Molecular genetic characterization of the ACTB-GLI fusion in pericytoma with t(7;12). Biochem Biophys Res Commun 2004; 325: 1318-1323. PMID: 15555571