Human pathology

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pancreatic acinar cell carcinoma

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Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma Pancreatic acinar cell carcinoma

Differential diagnosis

- pancreatic endocrine tumors
- solid-pseudopapillary tumors
- pancreatoblastoma
- ductal adenocarcinoma
- acinar cell adenoma
- focal acinar cell transformation
- microglandular carcinoma

Variants

- mixed acinar-endocrine carcinoma of the pancreas (15290275)

Molecular biology

- frequent allelic loss on chromosome 11p (50%)
- alterations in the APC/beta-catenin pathway (23.5%)

  • beta-catenin mutations
  • APC truncations
    - no K-ras mutation (8031464)

Allelotype: 11072247

1p36.31 4q26-31.1 17p13 11q 13q 15q15-22.1 3q 6q 8q 18q 21q
>70% >70% >70% 60%-70% 60%-70% 60%-70% 50%-60% 50%-60% 50%-60% 50%-60% 50%-60%

CGH (comparative genomic hybridization): 10862035

gains 1q42 12p11.2 Xq12-21
losses 16p13.2-p13.1 16q23

See also

- pancreatic tumors
- pancreatic acinar tumors