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palmoplantar keratodermas

Etiology

constitutional palmoplantar keratodermas

- Unna-Thorst syndrome
- Greither?s syndrome
- Olmsted?s syndrome
- Vohwinkel?s syndrome
- Homel-Evans syndrome
- Papillon-Lefèevre syndrome
- Mal de Maeda
- Gamborg Nielsen keratoderma
- Huriez?s syndrome (palmoplantar keratoderma with sclerodactyly)
- punctate keratoderma
- circumscribed keratoderma
- Naxos syndrome (MIM.601214) (mutation in the plakoglobin gene MIM.173325)
- striate palmoplantar keratoderma type II (mutation in the desmoplakin gene MIM.125647)

acquired palmoplantar keratodermas

- myxedema
- mycosis fungoides
- lymphoma
- multiple myeloma
- internal cancers
- arsenic exposure
- menopause
- bilateral oophorectomy (keratoderma climatericum)
- acanthosis nigricans (triple palms, pachydermatoglyphy)
- aquagenic palmoplantar keratoderma
- lichen planus
- pityriasis rubra pilaris
- drugs

  • infusion of glucan in AIDS
  • tegafur in colonic adenocarcinoma
  • fluorouracil

interdigital keratoderma

- toxics

  • herbicides
  • dioxin intoxication

References

- Christiano AM. Frontiers in keratodermas: pushing the envelope. Trends Genet. 1997 Jun;13(6):227-33. PMID: 9196328