Human pathology

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bone tumour

osteoid osteoma

osteogenic tumor

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Osteoid osteoma : central nidus and surrounding osteosclerosis Osteoid osteoma : central nidus Osteoid osteoma : interconnected bone trabeculae in nidus Osteoid osteoma : osteoid and osteoblastic activity in nidus

Osteoid osteoma is a benign bone-forming tumour with limited growth potential, inducing disproportionate pain

clinical features :

  • pain with nocturnal exacerbation, relieved by salicylates and NSAID
  • exquisite, localized tenderness

localization :

  • most common in long bones (femur)
  • virtually every bone (except sternum)

radiology :

  • dense cortical sclerosis around a radiolucent nidus
    • rarely : target-like lesion (if central sclerosis)

histology :

  • central nidus :
    • connective tissue, with differentiating osteoblasts producing osteoid and sometimes bone, with or without osteoclasts
  • surrounding sclerotic bone