Ossifying fasciitis is a rare benign tumour similar to nodular fasciitis histopathologically, but, morphologically, composed of metaplastic bone with calcification and chondroid differentiation.
This lesion may easily be misinterpreted as malignancy, clinically and histologically, because it presents as a rapidly growing mass originating from subcutaneous or deep fascial tissues.
These lesions are usually located in upper and lower extremities and trunk.
Clinical suspicion and accurate histopathology of this rare benign lesion is important because it is commonly misdiagnosed as a malignancy and results in unnecessary aggressively wide resection.
Synopsis
multinodular lesion
variable cellularity
myxoid areas
atypical fibroblasts
peripheral foci of immature woven bone with regulat osteoblasts
Differential diagnosis
nodular fasciitis
References
Clinical case of ossifying fasciitis of the hand. Kim JH, Kwon H, Song D, Shin OR, Jung SN. J Plast Reconstr Aesthet Surg. 2007;60(4):443-6. PMID: 17349604
Ossifying fasciitis. Doğan AI, Gedikoglu G, Demircin M, Ruacan S. Pathol Int. 2000 Feb;50(2):153-5. PMID: 10792775
Ossifying fasciitis of the nose. Innocenzi D, Giustini S, Barduagni F, Silipo V, Bosman C, Calvieri S. J Am Acad Dermatol. 1997 Aug;37(2 Pt 2):357-61.PMID: 9270548
Ossifying fasciitis. Daroca PJ Jr, Pulitzer DR, LoCicero J 3rd. Arch Pathol Lab Med. 1982 Dec;106(13):682-5. PMID: 6814399
Parosteal ossifying fasciitis of the hand. Case report. Ferrer-Roca O, Vilalta C, Ramon Soler R. Acta Orthop Belg. 1979;45(6):613-9. PMID: 122137