myelodysplasia
myelodysplastic syndromes
Cytogenetics
cytogentical anomalies in 50% of cases of myelodysplastic syndrome (MDS) and 80% of cases of secondary MDS (following chemotherapy or radiotherapy)
partial or complete chromosome deletion or addition
- del5q
- -7
- +8
- -Y
- del20q
balanced translocations
- MDS1-EVI1 in t(3;3) or t(3;21) translocations
- TEL in t(5;12)
- HIP1 in t(5;7)
- MLF1 in t(3;5)
- MEL1 in t(1;3)
References
Fenaux P. Chromosome and molecular abnormalities in myelodysplastic syndromes. Int J Hematol. 2001 Jun;73(4):429-37. PMID: 11503956