Synopsis
Immunochemistry
smooth muscle actin+ (SMA+)
BCL2+
cyclin D1+/-
CD44 (50 to 80%)
GLUT+ (25-50%)
- Glut1 positivity closely correlated with aggressive biologic behavior reflected by distant metastatic spread.
Localization
cutaneous leiomyosarcoma
subcutaneous leiomyosarcoma
deep leiomyosarcoma (soft tissues leiomyosarcoma)
retroperitoneal leiomyosarcoma
vascular leiomyosarcoma
uterine leiomyosarcoma
gastrointestinal leiomyosarcoma
leiomyosarcoma of external genitalia (vulva, penis) (14707873)
Cytogenetics
Most karyotypes are complex and no consistent aberrations.
CGH (12920222)
| losses | 10q | 13q14-q21 | 17p | 19p |
| gains | 1q | 5p14-pter | 17p |
LOH
3p LOH (12839673)
9p LOH (9p21 LOH) (15731925)
Chr.10 LOH (10079273)
Differential diagnosis
- smooth muscle cell tumors
- myofibroblastic tumors
EBV-associated smooth muscle tumors
- EBV-associated leiomyoma
- EBV-associated leiomyosarcoma
See also
- EBV-associated smooth muscle tumors
- EBV-associated leiomyoma
- EBV-associated leiomyosarcoma
References
Rao UN, Finkelstein SD, Jones MW. Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. Mod Pathol. 1999 Nov;12(11):1001-9. PMID: 10574596