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kindlin-1

Kindlin-1 is a human homolog of the Caenorhabditis elegans protein UNC-112, a membrane-associated structural/signaling protein that has been implicated in linking the actin cytoskeleton to the extracellular matrix (ECM).

Pathology

- Loss-of-function mutations were identified in the KIND1 encoding kindlin-1 in the Kindler’s symdrome

Keywords