iAMP21
Intrachromosomal amplification of chromosome 21 (iAMP21) involves amplification of the RUNX1 gene and duplication of chromosome 21, dup(21q).
iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in several tumors, as B-lineage acute lymphoblastic leukemia (ALL).
It defines a new cytogenetic subgroup in B-lineage acute lymphoblastic leukemia (ALL) with a poor prognosis.
Driver genes
See also
References
Robinson HM, Harrison CJ, Moorman AV, Chudoba I, Strefford JC. Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle. Genes Chromosomes Cancer. 2007 Apr;46(4):318-26. PMID: 17243167