Definition: Hydroa vacciniforme (HV) is a chronic photosensitivity disorder induced by ultraviolet radiation. Hydroa vacciniforme-like lymphoma is a rare cutaneous T-cell lymphoma occurring mainly in childhood.
There is an association between chronic latent Epstein-Barr virus (EBV) infection and both the benign skin disorder and the lymphoma.
AssociaTIONS
chronic EBV infection
Synopsis
epidermal ballooning degeneration
dense superficial and deep perivascular
periappendageal lymphoid cell infiltrates extending to the fat lobules
some blood vessels in the deep plexus infiltrated by predominantly CD4+ and TIA-1+ cytotoxic T cells
EBV genome found within tissue from three skin biopsies and peripheral blood cells.
References
Wu YH, Chen HC, Hsiao PF, Tu MI, Lin YC, Wang TY. Hydroa vacciniforme-like Epstein-Barr virus-associated monoclonal T-lymphoproliferative disorder in a child. Int J Dermatol. 2007 Oct;46(10):1081-6. PMID: 17910721