hepatoid yolk sac tumor
hepatoid pattern
20% of yolk sac tumor.
Synopsis
sheets of polygonal cells with abundant eosinophilic cytoplasm
hyaline globules
bile canaculi
sheets of medium-sized, round to polygonal neoplastic cells
- moderate amounts of eosinophilic cytoplasm
- round to oval nuclei with prominent nucleoli
homogeneous cellular proliferation
moderate cellular atypia
scattered mitotic activity
foci of more conventional areas of yolk sac tumor
- reticular pattern
- scattered intra- and extracellular hyaline globules
- occasional Schiller-Duval bodies
Immunochemistry
alpha-fetoprotein +
See also
yolk sac tumor
References
Moran CA, Suster S. Hepatoid yolk sac tumors of the mediastinum: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol. 1997 Oct;21(10):1210-4. PMID: 9331294