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hepatic fibrosis

Hepatic fibrosis Portal fibrosis in ARPKD at 21 weeks Fetal hepatic fibrosis at 29 weeks Ductal plate malformation (congenital hepatic fibrosis) Ductal plate malformation (congenital hepatic fibrosis) Ductal plate malformation (congenital hepatic fibrosis) Ductal plate malformation (congenital hepatic fibrosis) Ductal plate malformation (congenital hepatic fibrosis)

Topography

- portal fibrosis
- periportal fibrosis
- septal hepatic fibrosis
- portal and septal fibrosis (perilobular fibrosis)
- sinuosidal fibrosis (perisinusoidal fibrosis)
- pericentral fibrosis
- hepatic phlebosclerosis

Predisposition

- C5 (Complement factor 5) gene variants

References

- Hillebrandt S, Wasmuth HE, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, Schirin-Sokhan R, Wilkens G, Geier A, Lorenzen J, Kohl J, Gressner AM, Matern S, Lammert F. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet. 2005 Aug;37(8):835-43. PMID: 15995705

Keywords