Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds.
UDP-glucuronosyltransferases (UDPGTs) catalyze the addition of the glycosyl group from a nucleotide sugar to a small hydrophobic molecule (aglycone).
The conserved superfamily proteins all contain a 44-amino acid signature sequence in their C-terminal halves.
Pathology
germline mutations of UGT1A1 in Crigler-Najjar disease