Genic variants are more likely to alter gene function and affect disease risk than those that occur outside genes.
See also
genome-wide association studies
HapMap ENCODE
functionally important regions
genotyping
gene-centric genome-wide association studies
Types
missense variants
See also
variants of unknown significance (VUSs)
References
Jorgenson E, Witte JS. A gene-centric approach to genome-wide association studies. Nat Rev Genet. 2006 Nov;7(11):885-91. PMID: 17047687
Gibson G, Dworkin I. Uncovering cryptic genetic variation. Nat Rev Genet. 2004 Sep;5(9):681-90. PMID: 15372091