Synopsis
uniform round to oval cells arranged in nests and lobules separated by fibrovascular septae
- centrally-located nuclei demonstrate stippled chromatin
extensive hyalinization (Image 7)
large gangliocytic cells arranged in small clusters and scattered singly
- abundant eosinophilic cytoplasm
- eccentric vesicular nuclei
- single prominent nucleolus
areas composed of both the small blue cells and the ganglion cells can be present, with some cells showing features transitional between the two.
Localization
pelvic
spinal
- filum terminale
Immunohistochemistry
neuron specific enolase+
synaptophysin+
neurofilament+
GFAP- (Glial fibrillary acidic protein)
pankeratin-
Case records
[Case 223-http://path.upmc.edu/cases/case523.html]