fibrous hamartoma of infancy
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See also
- fibrous tumors Fibrous hamartoma of infancy is an uncommon fibroproliferative lesion of uncertain histogenesis that occurs only in infancy and childhood.
Synopsis
possible separate lesions
+/- infiltration into the superficial muscle
+/- infiltration and entrapment of nerves
possible rapid recurrence after initial surgery
Localization
spinal FHI (16933384)
knee (16532345), wrist (11436895)
Variants
multiple nodules with hypertrichosis (16700836)
recurrent FHI (15645249)
Electron microscopy
fibroblasts
-/+ myofibroblasts
/+ fusiform banded fibers (Luse bodies)
Cytogenetics
t(2;3)(q31;q21) (15794678)
complex translocation (6;12;8)(q25;q24.3;q13) (17116490)
Differential diagnosis
Association
Williams syndrome (17326745)
References
Rougemont AL, Fetni R, Murthy S, Fournet JC. A complex translocation (6;12;8)(q25;q24.3;q13) in a fibrous hamartoma of infancy. Cancer Genet Cytogenet. 2006 Dec;171(2):115-8. PMID: 17116490
Scott DM, Pena JR, Omura EF. Fibrous hamartoma of infancy. J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):857-9. PMID: 10534670
Dickey GE, Sotelo-Avila C. Fibrous hamartoma of infancy: current review. Pediatr Dev Pathol. 1999 May-Jun;2(3):236-43. PMID: 10191347
Groisman G, Lichtig C. Fibrous hamartoma of infancy: an immunohistochemical and ultrastructural study. Hum Pathol. 1991 Sep;22(9):914-8. PMID: 1916752
Maung R, Lindsay R, Trevenen C, Hwang WS. Fibrous hamartoma of infancy. Hum Pathol. 1987 Jun;18(6):652-3. PMID: 3596584
Greco MA, Schinella RA, Vuletin JC. Fibrous hamartoma of infancy: an ultrastructural study. Hum Pathol. 1984 Aug;15(8):717-23. PMID: 6540239
Mitchell ML, di Sant?Agnese PA, Gerber JE. Fibrous hamartoma of infancy. Hum Pathol. 1982 Jun;13(6):586-8. PMID: 7076241