fibrin-ring granuloma
Definition: Fibrin-ring granuloma (FRG) can be found in bone marrow or the liver. It is a subtype of epithelioid granuloma characterized by a central fat vacuole and annular peripheral fibrinoid materials.
FRG has been proven to be associated with many etiologies such as several infectious organisms (Coxiella burnett; Epstein-Barr Virus, EBV; cytomegalovirus, CMV; and hepatitis A virus), allopurinol induced hepatitis, Hodgkin lymphomas, and peripheral T-cell lymphoma.
Etiology
infections
- Coxiella burnetti (Q fever)
- Epstein-Barr Virus, EBV
- cytomegalovirus, CMV
- hepatitis A virus
- allopurinol induced hepatitis
tumors
- Hodgkin lymphomas
- peripheral T-cell lymphoma
References
Chung HJ, Chi HS, Cho YU, Jang S, Park CJ. [Bone marrow fibrin-ring granuloma: review of 24 cases] Korean J Lab Med. 2007 Jun;27(3):182-7. Korean. PMID: 18094573