cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinomas (SCC) are the second most commonly diagnosed cancers in fair-skinned people.
Allelotyping
9p LOH
3p LOH
9 LOH
2q LOH
8p LOH
13 LOH
Allelic gain
3q AG
8q AG
-copy number-neutral LOH
homozygous microdeletion on 9p23 at the protein tyrosine phosphatase receptor type D (PTPRD) locus
References
Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer. 2007 Jul;46(7):661-9. PMID: 17420988
Lima-Bessa KM, Menck CF. Skin cancer: lights on genome lesions. Curr Biol. 2005 Jan 26;15(2):R58-61. PMID: 15668158