Human pathology

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cutaneous Rosai-Dorfman disease

Rosai-Dorfman disease (RDD), previously known as sinus histiocytosis with massive lymphadenopathy, is a benign, idiopathic histiocytic proliferative disorder.

Synopsis

- solitary nodules
- large, well-circumscribed plaque
- large, pale, histiocytic cells (Rosai-Dorfman cells) exhibiting cytophagocytosis

Immunohistochemistry

- S-100+
- CD68+
- CD1a-

Electron microscopy

- Birbeck granules are absent

References

- Pitamber HV, Grayson W. Five cases of cutaneous Rosai-Dorfman disease. Clin Exp Dermatol. 2003 Jan;28(1):17-21. PMID: 12558621