curcumin
Curcumin (U1) has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities.
Pathology
Curcumin inhibits COX-2 expression and Erk1/2 activity in NSCLC cells. This inhibition is associated with decreased survival and enhanced induction of apoptosis.
Curcumin has shown to significantly reduce the growth of orthotopic human non-small cell lung tumors and improve survival of athymic mice.
Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse and is a potential therapy for inherited neuropathy (17701891)
See also
References
Khajavi M, Shiga K, Wiszniewski W, He F, Shaw CA, Yan J, Wensel TG, Snipes GJ, Lupski JR. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy. Am J Hum Genet. 2007 Sep;81(3):438-53. PMID: 17701891