Copy number abnormalities (CNAs) in tumor cells are presumed to affect expression levels of genes located in region of abnormality.
See also
copy number variations (CNVs)
References
Langdon JA, Lamont JM, Scott DK, Dyer S, Prebble E, Bown N, Grundy RG, Ellison DW, Clifford SC. Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes Chromosomes Cancer. 2006 Jan;45(1):47-60. PMID: 16149064