colorectal adenomas
Image Gallery
Cytogenetics
gain of chromosome 7 (most frequent anomaly)
- isolated trisomy 7 (7627942)
trisomy 20
tumoral trisomy 13
nosomy 18
arrangement of chromosome 1
- 1p deletion
- del(1)(p36) (1p36 deletion)
loss of 8p
gain of 8q
Molecular biology
Genetic alterations occur during the adenoma-carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer.
Videos
Polypectomy of a rectal polyp
References
Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer. 2006 Aug;45(8):781-9. PMID: 16708352
Bomme L, Bardi G, Pandis N, Fenger C, Kronborg O, Heim S. Chromosome abnormalities in colorectal adenomas: two cytogenetic subgroups characterized by deletion of 1p and numerical aberrations. Hum Pathol. 1996 Nov;27(11):1192-7. PMID: 8912830