carbonic anhydrases
Carbonic anhydrases (CAs) is a group of ubiquitously expressed metalloenzymes.
They are involved in numerous physiological and pathological processes, including gluconeogenesis, lipogenesis, ureagenesis, tumorigenicity and the growth and virulence of various pathogens.
In addition to the established role of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently emerged that CAIs could have potential as novel anti-obesity, anticancer and anti-infective drugs.
Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer?s disease.
References
Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov. 2008 Jan 2; PMID: 18167490