Human pathology

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bronchial carcinoma in situ

bronchial CIS

Molecular biology

- TP53 mutation

CGH

Losses 5q21
Gains 3q25-26

Allelotyping

- 4p16 LOH

Amplication

- 4q12 amplification

References

- Foster NA, Banerjee AK, Xian J, Roberts I, Pezzella F, Coleman N, Nicholson AG, Goldstraw P, George JP, Rabbitts PH. Somatic genetic changes accompanying lung tumor development. Genes Chromosomes Cancer. 2005 Sep;44(1):65-75. PMID: 15937994