Bilirubin is the normal major pigment found in bile. It is derived from hemoglobin but contains no iron. Its normal formation and excretion are vital to health, and jaundice is a common clinical disorder caused by excesses of this pigment within cells and tissues. Bilirubin is a potent antioxidant but can be toxic at high concentrations.
Pathology
bilirubin metabolism disorders
Features
bilirubin metabolism
References
Rigato I, Ostrow JD, Tiribelli C. Bilirubin and the risk of common non-hepatic diseases. Trends Mol Med. 2005 Jun;11(6):277-83. PMID: 15949769
Ostrow JD, Pascolo L, Brites D, Tiribelli C. Molecular basis of bilirubin-induced neurotoxicity. Trends Mol Med. 2004 Feb;10(2):65-70. PMID: 15102359