Function

 MAP3K5 encodes a mitogen-activated protein kinase kinase kinase of the JNK/MAPK signaling pathway

Pathology

 amplification and overexpression of ASK1 or MAP3K5 gene at 6q23 band in malignant fibrous hsitiocytoma (#15034865#)

• MAP3K5 could inhibit the adipocytic differentiation process of the tumor cells. (#15034865#)
• Treatment of a cell line with specific inhibitors of ASK1 protein resulted in the bypass of the differentiation block and induction of a strong adipocytic differentiation. (#15034865#)