Human pathology

Home page > A. Molecular pathology

A. Molecular pathology

Gallery of this section's images

ACTNs

Alpha-actinin and adherens junction

ALK

ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor

AMACR

p504s in prostatic prostatic nephrogenic adenoma.

ATM

ATM signaling pathway BRCAs-ATR-ARM pathway

ATP depletion

ATP depletion in cell injury

BAD

BAD and AKT signaling

BAZ1B

WSTF (BAZ1B) and the control of gene expression by Vitamin D (...)

BBS4

BBS4 and centrosome (From Nature Review Genetics)

BCL2

BCL2 immunostaining in tonsilla BCL2 immunostaining in adenoid BCL2 immunostaining in nodal follicular hyperplasia

BCL6

BCL6 partners in B-cell lymphoma

BCR/ABL

Inhibition of Cellular Proliferation in CML by Gleevec

BIRCs

BIRCs (IAPs)

BMPR1A

Juvenile polyps in juvenile polyposis

BMPs

BMPs in cardiomyocyte differentiation

BPAG1

BPAG1 and hemidesmosome

BTGs

BTG family proteins and cell cycle regulation

cadherin-catenin complex

Beta-catenin-cadherin complex

calcium influx

Calcium influx and cell injury

CARD15

CARD15 (NOD2) function

carnitine

Mitochondrial Carnitine Palmitoyltransferase (CPT) System

CASP9

CASP9 and AKT signaling

caspases pathway

Caspases pathway

CASPs

Caspases pathway The caspases pathway

catalase

Function of catalase

catenins/APC pathway

The beta-catenin-APC complex in the Wnt signaling pathway The beta-catenin-APC complex in the Wnt signaling pathway

CCNB1

Cyclin-B1 intercation with PTCH and the SHH pathway

CCNs

Cell cycle regulation by cyclins

CD15

CD15 in classic Hodgkin lymphoma CD15 immunolabeling in lymphocyte-rich classic Hodgkin lymphoma CD15 immunolabeling in lymphocyte-rich classic Hodgkin lymphoma

CD18

CD18 and granulocytic diapedesis

CD1a

Cutaneous Langerhans histiocytosis CD1a+ Cutaneous Langerhans histiocytosis Cutaneous Langerhans histiocytosis

CD20

CD20 positivity in a large cell lymphoma CD20 immunostaing in follicular lymphoid hyperplasia CD20 immunostaining of pulmonary follicular lymphoid hyperplasia CD20+ nodules in progreesive transformation of germinal centers (...) CD20+ nodules in progreesive transformation of germinal centers (...) CD20+ nodules in progreesive transformation of germinal centers (...) CD20+ nodules in nodular lymphocyte predominant Hodgkin lymphoma CD20 in lung: slight bronchi-associated lymphoid tissue (BALT) (...) CD20 immunostaining of the spleen: lymphoid follicles of the white pulp are (...) CD20 immunostaining of a normal tonsil CD20 immunostaining in nodal follicular lymphoid hyperplasia

CD30

CD30 in classic Hodgkin lymphoma CD30+ macroscopical nodules in classic Hodgkin lymphoma. CD30+ macroscopical nodules in classic Hodgkin lymphoma.

CD3s

CD3 immunostaining of tonsilla

CD68

CD68 immunostaing of the splenic red pulp (labelling of red pulp (...)

CD99

Ewing sarcoma: CD99 positivity Ewing sarcoma: CD99 positivity Ewing sarcoma: CD99 positivity

CDH1

E-cadherin and adherens junction

CDK4

RB/CDK4 pathway Gatekeepers pathways

CDKs

Cell cycle regulation by CDKs

CEA

CEA in microvillous inclusion disease

cell adhesion molecules

cell cycle checkpoint kinases

ceramide

Ceramides in SAPKs signaling pathway

cetone bodies

From acetyl-CoA to cetone bodies

CFTR

CFTR and beta 2 adrenergic receptor (b2AR) pathway

CHEK2

CHEK2 and the BRCAs DNA repair system

CLIP

CLIP and antigen presentation

COL17A1

BPAG2 (COL17A1) and hemidesmosome

CTNNB1

beta-catenin and cadherin pathway Beta-catenin and adherens junction

CTNND1

Delta-catenin and adherens junction

CTTNA1

Alpha-catenin and adherens junction

cystoproteins

Cystoproteins and their cellular functions

cytosine

cytoskeletal proteins

Cytoskeleton and contact proteins

desmin

Desmin immunolabeling of embryonal rhabdomyosarcoma Desmin immunolabeling of embryonal rhabdomyosarcoma Desmin immunolabeling of embryonal rhabdomyosarcoma

desmoglein-3

Desmosomal proteins

DNA double-strand break repair

DNA single-strand breaks

DNA single-strand damage repair

DOPA

Melanin biosynthesis from DOPA

DSCs

Desmocollins and desmosome

DSG4

Desmosomal proteins

DSGs

Desmogleins and desmosome

DSP

Desmoplakins and desmosome

DTNs

Dystrobrevins and the dystrophin-glycoprotein complex

dyneins

Dynein arms in cilia and basal body

dystroglycan

Dystroglycan

dystrophin

Dystrophin

dystrophin-glycoprotein complex

The dystrophin-glycoprotein complex

E2F1

Cell cycle regulation by RB/E2F

EGF

EGF signaling pathways

eicosanoids

Eicosanoids metabolism

ELKs

ELKs in the RAS-RAF-MAPKs (ERKs) signaling pathway

ETV6

ETV6 partners

EWSR1

EWS partners in fusion genes

FA complex

FA complex and the BRCA1 pathway

FANC/BRCA1/BRCA2/ATM/NBS1 signaling pathway

BRCAs-ATR-ARM pathway

FANCs

The FANCs and the BRCA1-ATM pathway

FGFRs

FGFRs and PTPN11 (Shp-2)

FGFs

FGFs and PTPN11 (Shp-2)

fibronectin

Extracellular matrix-cell interactions

FOXO3A

FOXO3A and DNA damage

FRAP1

PI3K/Akt signaling PI3K/PTEN/AKT signaling pathway mTOR Signaling Pathway

FSCNs

Fascin in classic Hodgkin disease

fusion proteins

Fusion genes and fusion transcripts

GABA receptors

GABA receptors cycle

GLI

Cubitus interruptus function

glutamate

Synthesis of gamma-hydroxybutyrate from gluatamate Glutamate catabolism Glutamate in Malate-Aspartate pathway Glutamate to urea cycle

glutathione reductase

Function of glutathione reductase

glycine

Glycine-Serine biosynthesis

glycosphingolipid

Glycosphingolipids and sphingolipidoses (from 12667757)

GPXs

Function of glutathione peroxidases

growth factors

Grpwth factors and PI3K/PTEN/AKT signaling pathway

H2O2

H2O2 generation (From Robbins)

HBs

hemosiderin

Pulmonary hemosiderosis (encephalopathy with recurrent aspirations) Pulmonary hemosiderosis (encephalopathy with recurrent aspirations)

ICAM1

ICAM1 and granulocytic diapedesis

ICAM2

ICAM2 and granulocytic diapedesis

ICAMs

ICAM1 and ICAM2 and granulocytic diapedesis

inhibitors of the proteasome

Ubiquitin-Proteasome System

ITGA6

ITGA6 and hemidesmosomes

ITGB2

CD18 and diapedesis

ITGB4

ITGB4 and hemidesmosomes

ITGBs

Beta-integrinas and the PI3K/PTEN/AKT signaling pathway

ITGs

Integrins signaling pathway Extracellular matrix-cell interactions beta-integrins and the PI3K/PTEN/AKT signaling pathway

JAKs

Stat3 Signaling Pathway

JAKs/STATs signaling pathways

Stat3 Signaling Pathway

JNK/MAPK signaling pathway

MAPKinase Signaling Pathway

JUP

Plakoglobin and desmosome

Ki67

Ki67 in Burkitt lymphoma Ki67 in Burkitt lymphoma

kinesins

Mechanism of kinesin-dependent vesicle transport along a microtubule

laminins

Extracellular matrix-cell interactions Laminin and sarcomere

LDL

The LDL receptor pathway and regulation of cholesterol metabolism

LEP

Reversal of Insulin Resistance by Leptin

lipofuscins

Lipofuscin in Kuppfer cells Lipofuscin in portal macrophages Lipofuscin in portal macrophages Lipofuscin in portal macrophages Lipofuscin in portal macrophages Lipofuscin in portal macrophages Lipofuscin in portal macrophages

MADH4

Juvenile polyps in juvenile polyposis

mannose receptors

Mannose receptor and phagocytosis (From Robbins)

MAP3K5

MAPKinase Signaling Pathway

MAP3Ks

MAP3Ks (MEKKs) in RAS-RAF-MAPKs (ERKs) signaling pathways

MAPK signaling pathway

The RAS-ERk signaling pathway MAPKinases signaling pathway

MAPKs

p38 MAPK signaling pathway MAPKinases signaling pathway Beta-integrins, MAPKs (ERKs) and the PI3K/PTEN/AKT signaling (...)

MC1R

MC1R receptor

melanins

Melanins biosynthesis

membrane lipid peroxidation

Cellular injury by lipid peroxydation Cellular injury by lipid peroxidation

MHC proteins

Antigen presentation by MHC proteins

MITF

MLL

MYC

MYC and MAPKs signaling pathways

NADH

NADH in malate-aspartate shuttle

NF-kappaB

NFkappaB signaling pathway NF-kappaB activation by RIPK2 and CARD15

Notch inhibitors

Notch signaling pathway

NOTCHs

Notch signaling pathway

oxydative phosphorylation

Oxydative phosphorylation

p14(ARF)

P14(ARF)-HDM2-P53 signaling pathway ARF, MDM2, p53 and the cell cycle The ARF-HDM2-P53 pathway

palissaded granulomatous and neutrophilic dermatitis

PARK2

Parkin-UPS pathway

PECAM1

PECAM1 and granulocytic diapedesis

peptide bond

Peptidic bond - Animated gif

peroxisome proliferators

Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

phosphoinositides

PTEN-mTOR signaling pathway PIP3-PTEN pathway A map of phosphoinositide metabolism.

phospholipase-A

PLAs and SAP kinases

PI3K/PTEN/AKT signaling pathway

AKT-PIP3 signaling pathway PI3K/Akt signaling mTOR Signaling Pathway

PIK3s

PI3K/PTEN/AKT signaling pathway

PIP2

PIP2 and the PI3K/PTEN/AKT signaling pathway PIP2 and the PI3K/PTEN/AKT signaling pathway

PIP3

PI3K/PTEN/AKT signaling pathway PIP3 and the PI3K/PTEN/AKT signaling pathway

PKD1

PKD2

PKP1

Plakophilins in desmosome

PKP2

Plakophilins in desmosome

PKP3

Plakophilins and desmosome

PLA2s

SAP kinases and PLAs

PLAG1

Lipoblastoma

plakins

The plakins, a family of modular proteins.

PLEC1

Plectin and hemidesmosome

PML

Regulation of transcriptional activity by PML

PML/RARA

PML/RARA pathway

polyglutamine repeat diseases

Polyglutamine mutations

postsynpatic proteins

Synaptic Proteins at the Synaptic Junction

PPARs

Gene Regulation by Peroxisome Proliferators via PPAR-alpha

presenilin-1

Presenilin and the Notch signaling pathway Presenilin-1 and the Notch and Wnt signaling pathways

presenilins

Prsenilins and the Notch signaling pathway Presenilin-1 and the beta-catenin pathway

PRF1

The Mechanism of Action of Perforin

promoter

Gene promoter

proteasomal degradation

Proteasomal degradation pathway

protein interactions maps

Symbol definitions and map conventions

protein misfolding

Protein folding (From Robbins)

protein-DNA interactions

Protein-DNA interactions

PTEN

PTEN dependent cell cycle arrest and apoptosis mTOR Signaling Pathway

PTPN11

FGFs and PTPN11 (Shp-2)

PXN

Paxillin in focal contacts

pyrimidine

Pyrimidine nucleobase structure Thymine structure Cytosine Uracil

RABs

Rab GTPases pathways RABs proteins in targeting and fusion of vesicles with the target (...) RABs and vesicular transport (From PMID 11796263)

RAC1

RAC1 and the SAP kinase signaling pathway

RAF1

Example of RAS-RAF-MAPK signaling

RAFs

Example of RAS-RAF-MAPK (ERKs) signaling RAS-RAF-MAPK (ERK) signaling pathway

RARA

PML/RARA pathway

RASs

Ras signaling pathway

RB

RB/CDK4 pathway Cell cycle regulation by RB/E2F

RB/E2F pathway

Cell cycle regulation by RB/E2F

reactive oxygen species

Reactive oxygen species (ROS) in cell injury. From Robbins

RHO

Rhodopsin

Rho kinases

Rho and cell cycle

RIPK2

RIPK2 (RIP2) and CARD15 (NOD2)

SAPKs

SAPKs siganling pathway

SAPs

Synaptic Proteins at the Synaptic Junction

sarcoglycans

Sarcoglycans

SELL

L-selectin and granulocytic diapedesis

SELP

P-selectin in leukocytic diapedesis P-selectin and granulocytic diapedesis

SELPLG

SELPLG in granulocytic diapedesis

serine

Serine-Glycine biosynthesis

SHH-GLI signaling pathway

SHH-GLI signaling pathway SHH and cell cycle

sialyl-Le

Sialyl-Le and granulocytic diapedesis

SLC2A1

GLUT1 in infantile hemangioma GLUT1 in infantile hemangioma

smooth muscle actin

Smooth muscle actin expression in infantile myofibromatosis Smooth muscle actin labeling of muscularis mucosae and muscularis (...) Smooth muscle actin (SMA) immunolabeling in ETV6-NTRK3+ congenital (...) Smooth muscle actin (HHF35) immunolabeling in ETV6-NTRK3+ congenital (...) Smooth muscle actin (SMA) immunolabeling of a gastric Peutz-Jeghers (...)

SNTGs

Syntrophins and the dystrophin-glycoprotein complex

somatic hypermutation

Somatic hypermutation

sphingolipids

Sphingolipids biosynthesis Spingolipids and sphingolipidoses (from 12667757)

STATs

Stat3 Signaling Pathway

subcutaneous fat necrosis of the newborn

superoxide

O2- generation

SYP

Synaptophysin immunostaining in bone marrow localization of a (...)

talins

Talins in focal contacts

TFE3

TFE3 positivity in pediatric renal cell carcinoma TFE3 positivity in pediatric renal cell carcinoma TFE3 positivity in pediatric renal cell carcinoma

TFEB

TFEB positivity in HMB45+ renal cell tumor TFEB positivity in HMB45+ renal cell tumor TFEB positivity in HMB45+ renal cell tumor TFEB positivity in HMB45+ renal cell tumor

TGF-beta signaling pathway

TGFbeta proteins signaling pathway

thymine

Thymine chemical structure

tinea versicolor

TP53

TP53 pathway p53 and genome integrity p53 and HPV proteins p53 and the cell cycle p53-MDM2 signaling pathway

trichotillomania

trinucleotide repeat diseases

Mechanisms of polyglutamine diseases (From Nature Review Genetics) Pathogenesis of Friedreich ataxia Pathogenesis of Fragile X syndrome List of trinucleotid repeat expansion diseases Molecular features of trinucleotid repeat expansion diseases

TSC1

TSC and the mTOR Signaling Pathway

TSC2

TSC and the mTOR Signaling Pathway

TSCs

TSCs and the PI3K/PTEN/AKT signaling pathway

tumor suppressor genes

Tumor suppressor genes and signaling pathways

ubiquitin-proteasome system

Proteasome pathway

ubiquitination

Ubiquitin Proteasome System (UPS)

UBLs

SUMOylation pathway

urea cycle

Aminoacids to urea cycle

VCL

Vinculin in focal contacts Vinculin in adherens junctions Vinculin (VCL) and the dystrophin-glycoprotein complex

VDR

Control of Gene Expression by Vitamin D Receptor (VDR)

VIL1

villin-1 in enterocytic brush border

VIL2

VIL2 (Ezrin) and the CFTR and beta 2 adrenergic receptor (b2AR) (...) VIL2 (Ezrin) and the calpain cell motility pathway Villins in enterocytic brush border

WNT signaling pathway

WNT signaling pathway beta-catenin and cadherin pathway Wint signaling

WT1

WT1 structure

ZXN

Zyxin and contact proteins

Index

Show all

A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
R
S
T
U
V
W
X
Y
Z