Anaplastic astrocytoma (AA, WHO grade III) is, second to Glioblastoma, the most common and most malignant type of adult CNS tumour.
Molecular biology
loss of both wild-type copies of genes in the RB1 pathway (15970925)
amplification and overexpression of CDK4
References
Backlund LM, Nilsson BR, Liu L, Ichimura K, Collins VP. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. Br J Cancer. 2005 Jul 11;93(1):124-30. PMID: 15970925